Publication

    • 19

      Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells

      Morishima T*, Takahashi K, Chin DWL, Wang Y, Tokunaga K, Arima Y, Matsuoka M, Suda T, Takizawa H*

      Cancer Sci., 2023 Oct 26. doi: 10.1111/cas.15994

    • 18

      Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals

      Wang Y, Morishima T, Sezaki M, Sato R, Nakato G, Fukuda S, Kobiyama K, Ishii KJ, Li Y*, Takizawa H*

      EMBO Rep., 2023 Oct 23:e57485. doi: 10.15252/embr.202357485

    • 17

      GPRC5C Drives Branched-Chain Amino Acid Metabolism in Leukemogenesis

      Zhang YW, Velasco-Hernandez T, Mess J, Lalioti ME, Romero-Mulero MC, Obier N, Karantzelis N, Rettkowski J, Schönberger K, Karabacz N, Jäcklein K, Morishima T, Trincado JL, Romecin P, Martinez-Moreno A, Takizawa H, Shoumariyeh K, Renders S, Zeiser R, Pahl HL, Béliveau F, Hébert J, Lehnertz B, Sauvageau G, Menendez P, Cabezas-Wallscheid N*

      Blood Adv., 2023 Aug 28;bloodadvances. 2023010460. doi: 10.1182/bloodadvances.2023010460

    • 16

      IL-6 Levels Correlate with Prognosis and Immunosuppressive Stromal Cells in Patients with Colorectal Cancer

      Yamamoto T, Tsunedomi R, Nakajima M, Suzuki N, Yoshida S, Tomochika S, Xu M, Nakagami Y, Matsui H, Tokumitsu Y, Shindo Y, Watanabe Y, Iida M, Takeda S, Hazama S, Tanabe T, Ioka T, Hoshii Y, Kiyota A, Takizawa H, Kawakami Y, Ueno T, Nagano H*

      Ann Surg Oncol., 2023 Aug;30(8):5267-5277. doi: 10.1245/s10434-023-13527-y

    • 15

      Humanized mouse models with endogenously developed human natural killer cells for in vivo immunogenicity testing of HLA class I-edited iPSC-derived cells

      Flahou C, Morishima T, Higashi N, Hayashi Y, Xu H, Wang B, Zhang C, Ninomiya A, Qiu W-Y, Yuzuriha A, Suzuki D, Nakamura S, Manz M, Kaneko S, Hotta A, Takizawa H, Eto K*, Sugimoto N*

      Biochem Biophys Res., 2023 Jun 25;662:76-83. doi: 10.1016/j.bbrc.2023.04.067

    • 14

      Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

      Yokomizo-Nakano T, Hamashima A, Kubota S, Bai J, Sorin S, Sun Y, Kikuchi K, Morii M, Iimori M, Kanai A, Iwama A, Huang G, Kurotaki D, Takizawa H, Matsui H, Sashida G

      J Exp Med., 2023 Jul 3;220(7):e20220962. doi: 10.1084/jem.20220962

    • 13

      IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia

      Liu X, Sato N, Yabushita T, Tamura M, Asada S, Fujino T, Fukushima T, Yonezawa T, Tanaka Y, Fukuyama T, Tsuchiya A, Shikata S, Iwamura H, Saito M, Kinouchi C, Komatsu K, Yamasaki S, Shibata T, Sasaki AT, Schibler J, Wunderlich M, O’Brien E, Mizukawa B, Mulloy JC, Sugiura Y, Takizawa H, Shibata T, Miyake K, Kitamura T, Goyama S*

      EMBO Mol Med., 2023 Jan 11;15(1):e15631. doi: 10.15252/emmm.202115631

    • 12

      Hematopoietic stem and progenitor cells integrate microbial signals to promote post-inflammation gut tissue repair

      Sezaki M#, Hayashi Y#, Nakato G, Wang Y, Nakata S, Biswas S, Morishima T, Fakruddin M, Moon J, Ahn S, Kim P, Miyamoto Y, Baba Y, Fukuda S, Takizawa H*

      EMBO J., 2022 Nov 17;41(22):e110712. doi: 10.15252/embj.2022110712

    • 11

      Bone marrow imaging reveals the migration dynamics of neonatal hematopoietic stem cells

      Takihara Y, Higaki T, Yokomizo T, Umemoto T, Ariyoshi K, Hashimoto M, Sezaki M, Takizawa H, Inoue T, Suda T, Mizuno H

      Commun Biol. 2022 Aug 2;5(1):776. doi: 10.1038/s42003-022-03733-x

    • 10

      Quantitative analysis of sympathetic and nociceptive innervation across bone marrow regions in mice

      Fujita S, Morikawa T, Tamaki S, Sezaki M, Takizawa H, Okamoto S, Kataoka K, Takubo K

      Exp. Hematol., 2022 Aug-Sep;112-113:44-59.e6. doi: 10.1016/j.exphem.2022.07.297

    • 9

      IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice

      Kovtonyuk LV, Caiado F, Garcia-Martin S, Manz EM, Helbling PM, Takizawa H, Boettcher S, Al-Shahrour F, Nombela-Arrieta C, Slack E, Manz MG*

      Blood, 2022 Jan 6;139(1):44-58. doi: 10.1182/blood.2021011570

    • 8

      Inflammation regulates haematopoietic stem cells and their niche

      Ho NP, Takizawa H*

      Int. J. Mol. Sci., 2022 Jan 20;23(3):1125. doi: 10.3390/ijms23031125

    • 7

      Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans

      Mende N, Bastos HP, Santoro A, Mahbubani KT, Ciaurro V, Calderbank EF, Quiroga Londoño M, Sham K, Mantica G, Morishima T, Mitchell E, LidonniciMR, Meier-Abt F, Hayler D, Jardine L, Curd A, Haniffa M, Ferrari G, Takizawa H, Wilson NK, Göttgens B, Saeb-Parsy K, Frontini M, Laurenti E

      Blood, 2022 Jun 9;139(23):3387-3401. doi: 10.1182/blood.2021013450

    • 6

      Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors

      Tanaka Y, Takeda R, Fukushima T, Mikami K, Tsuchiya S, Tamura M, Adachi K, Umemoto T, Asada S, Watanabe N, Morishita S, Imai M, Nagata M, Araki M, Takizawa H, Fukuyama T, Lamagna C, Masuda ES, Ito R, Goyama S, Komatsu N, Takaku T, Kitamura T*

      Nat Commun., 2022 Jan 12;13(1):271. doi: 10.1038/s41467-021-27928-8

    • 5

      Impact of cerebrovascular comorbidity on prognosis in Japanese patients undergoing PCI: 1-year data from Japanese multicenter registry (KICS)

      Ahmed K, Arima Y, Tabata N, Ishii M, Sato R, Yamashita T, Yamanaga K, Takizawa H, Hokimoto S, Sueta D, Araki S, Fujisue K, Takashio S, Fujimoto K, Shimomura H, Tsunoda R, Hirose T, Sato K, Kikuta K, Sakaino N, Nakamura S, Yamamoto N, Matsumura T, Kajiwara I, Tayama S, Sakamoto T, Nakao K, Oshima S, Yamamoto E, Sakamoto K, Kaikita K, Matsushita K, Tsujita K

      Heart Vessels., 2022 Jun;37(6):911-918. doi: 10.1007/s00380-021-01997-7

    • 4

      Remote control of neural function by X-ray-induced scintillation

      Matsubara T, Yanagida T, Kawaguchi N, Nakano T, Yoshimoto J, Sezaki M, Takizawa H, Tsunoda SP, Horigane SI, Ueda S, Takemoto-Kimura S, Kandori H, Yamanaka A, Yamashita T*

      Nat Commun., 2021 Jul 22;12(1):4478. doi: 10.1038/s41467-021-24717-1

    • 3

      CD271+CD51+PALLADIN- human mesenchymal stromal cells possess enhanced ossicle-forming potential

      Sezaki M, Biswas S, Nakata S, Oshima M, Koide S, Ho NPY, Okamoto N, Miyamoto T, Iwama A, Takizawa H

      Stem Cells Dev., 2021 Jul 15;30(14):725-735. doi: 10.1089/scd.2021.0021

    • 2

      Fit-For-All iPSC-Derived Q1 Cell Therapies and Their Evaluation in Humanized Mice with NK Cell Immunity.

      Flahou C, Morishima T, Takizawa H, Sugimoto N*.

      Front Immunol., 2021 Apr 2;12:662360. doi: 10.3389/fimmu.2021.662360

    • 1

      Autophagy is dispensable for the maintenance of hematopoietic stem cells in neonates

      Hashimoto M, Umemoto T, Nakamura-Ishizu A, Matsumura T, Yokomizo T, Sezaki M, Takizawa H, Suda T*

      Blood Adv., 2021 Mar 23;5(6):1594-1604. doi: 10.1182/bloodadvances.2020002410

    • 37

      Immuno-modulation of hematopoietic stem and progenitor cells in inflammation

      Sezaki M#, Hayashi Y#, Wang Y, Johansson A, Umemoto T, Takizawa H*

      Front Immunol., 2020 Nov 24;11:585367. doi: 10.3389/fimmu.2020.585367

    • 36

      Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages

      Nasser H#, Adhikary P#, Abdel-Daim A#, Noyori O, Panaampon J, Kariya R, Okada S, Ma W, Baba M, Takizawa H, Yamane M, Niwa H, Suzu S*

      Cell Death Discov., 2020 Jul 23;6:63. doi: 10.1038/s41420-020-00300-3

    • 35

      Genetic fingerprint defines hematopoietic stem cell pool size and function

      Morishima T*, Takizawa H*

      Haematologica, 2020 Mar;105(3):526-528. doi: 10.3324/haematol.2019.241299

    • 34

      Innate immune signal-mediated regulation and alterations in hematopoiesis

      Hayashi Y, Takizawa H*

      Rinsho Ketsueki. 2020;61(6):651-656. doi: 10.11406/rinketsu.61.651

    • 33

      iPSC-derived platelets depleted of HLA class-I are inert to anti-HLA class-I and NK cell immunity

      Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, Akasaka M, Nakamura S, Higashi N, Xu H, Matsumoto T, Fujio K, Manz MG, Hotta A, Takizawa H, Eto K, Sugimoto N

      Stem Cell Rep., 2020 Jan 14;14(1):49-59. doi: 10.1016/j.stemcr.2019.11.011

    • 32

      Discrimination of dormant and active hematopoietic stem cells by G0 marker reveals dormancy regulation by cytoplasmic calcium

      Fukushima T, Tanaka Y, Hamey FK, Chang CH, Oki T, Umemoto T, Asada S, Hayashi Y, Fujino T, Yonezawa T, Takeda R, Kawabata KC, Fukuyama T, Goyama S, Takizawa H, Ishihama Y, Honda H, Göttgens B, and Kitamura T*

      Cell Rep., 2019 Dec 17;29(12):4144-4158.e7. doi: 10.1016/j.celrep.2019.11.061

    • 31

      Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

      Hayashi Y, Goyama S, Liu X, Tamura M, Asada S, Tanaka Y, Fukuyama T, Wunderlich M, O'Brien E, Mizukawa B, Yamazaki S, Matsumoto A, Yamasaki S, Shibata T, Matsuda K, Sashida G, Takizawa H, Kitamura T*

      Nat Commun., 2019 Oct 25;10(1):4869. doi: 10.1038/s41467-019-12555-1

    • 30

      Fate distribution and regulatory role of human mesenchymal stromal cells in engineered hematopoietic bone organs

      Bourgine PE, Fritsch K, Pigeot S, Takizawa H, Kunz L, Kokkaliaris KD, Coutu DL, Manz MG, Martin I, Schroeder T

      iScience., 2019 Sep 27;19:504-513. doi: 10.1016/j.isci.2019.08.006

    • 29

      Hlf marks the developmental pathway for hematopoietic stem cells but not for erythroid-myeloid progenitors

      Yokomizo T*, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, , Nakagata N, Mori S, Kurokawa M, Tenen DG, Osato M, Suda T*, Komatsu N

      J Exp Med., 2019 Jul 1;216(7):1599-1614. doi: 10.1084/jem.20181399

    • 28

      Development of the Hematopoietic System: Role of Inflammatory Factors

      Hayashi Y#, Sezaki M#, Takizawa H*

      Wiley Interdiscip Rev Dev Biol., 2019 Jul;8(4):e341. doi: 10.1002/wdev.341

    • 27

      Thrombopoietin metabolically primes hematopoietic stem cells to megakaryocyte lineage differentiation

      Nakamura-Ishizu A, Umemoto T, Matsumura T, Stumpf PS, Takihara Y, Takizawa H, O’Neil A, Abdul Majeed AB, MacArthur BD, and Suda T

      Cell Rep., 2018 Nov 13;25(7):1772-1785. e6. doi: 10.1016/j.celrep.2018.10.059

    • 26

      Inflammation and early hematopoiesis

      Takizawa H*, Hayashi Y

      Rinsho Ketsueki. 2018;59(10):1955-1961. doi: 10.11406/rinketsu.59.1955

    • 25

      Engineered humanized bone organs maintain human hematopoiesis in vivo

      Fritsch K, Pigeot S, Bourgine PE, Feng X, Schroeder T, Martin I, Manz MG, Takizawa H*

      Exp Hematol., 2018 May;61:45-51. e5. doi: 10.1016/j.exphem.2018.01.004

    • 24

      Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness

      Takizawa H*, Fritsch K, Kovtonyuk LV, Saito Y, Yakkala C, Jacobs K, Ahuja AK, Lopes M, Hausmann A, Hardt WD, Gomariz Á, Nombela-Arrieta C and Manz MG

      Cell Stem Cell., 2017 Aug 3;21(2):225-240. doi: 10.1016/j.stem.2017.06.013

    • 23

      Impact of inflammation on early hematopoiesis and the microenvironment

      Takizawa H*and Manz MG

      Int J Hematol., 2017 Jul;106(1):27-33. doi: 10.1007/s12185-017-2266-5

    • 22

      Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells and the Bone Marrow Microenvironment

      Kovtonyuk LV, Fritsch K, Feng X, Manz MG, Takizawa H*

      Front Immunol., 2016, Nov 14;7:502. doi: 10.3389/fimmu.2016.00502

    • 21

      MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia

      Rauch PJ, Ellegast JM, Widmer CC, Fritsch K, Goede JS, Valk PJ, Löwenberg B, Takizawa H, Manz MG*

      Blood, 2016 Nov 3;128(18):2253-2257. doi: 10.1182/blood-2016-04-711986

    • 20

      Hematopoietic stem cell response to inflammation

      Takizawa H*

      Rinsho Ketsueki. 2016 Aug;57(8):1059-1065. doi: 10.11406/rinketsu.57.1059

    • 19

      Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo

      Kovtonyuk LV, Manz MG, Takizawa H*

      Blood, 2016 Jun 23;127(25):3175-3179. doi: 10.1182/blood-2015-09-669929

    • 18

      LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance

      Ziegler P, Boettcher S, Takizawa H, Manz MG, Brümmendorf TH

      Ann Hematol., 2016 Jan;95(2):173-178. doi: 10.1007/s00277-015-2550-5

    • 17

      BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

      Berres ML, Lim KP, Peters T, Price J, Takizawa H, Salmon H, Idoyaga J, Ruzo A, Lupo PJ, Hicks MJ, Shih A, Simko SJ, Abhyankar H, Chakraborty R, Leboeuf M, Beltrão M, Lira SA, Heym KM, Clausen BE, Bigley V, Collin M, Manz MG, McClain K, Merad M, Allen CE

      J Exp Med., 2014 Apr 7;211(4):669-83. doi: 10.1084/jem.20130977

    • 16

      The analysis, roles and regulation of quiescence in hematopoietic stem cells

      Nakamura-Ishizu A, Takizawa H, Suda T*

      Development., 2014 Dec;141(24):4656-4666. doi: 10.1242/dev.106575

    • 15

      Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F

      Lundberg P#, Takizawa H#, Kubovcakova L#, Guo G, Hao-Shen H, Dirnhofer S, Orkin SH, Manz MG, Skoda RC

      J Exp Med., 2014 Oct 20;211(11):2213-2230. doi: 10.1084/jem.20131371

    • 14

      A comprehensive surface proteome analysis of myeloid leukemia cell lines for therapeutic antibody development

      Strassberger V, Gutbrodt KL, Krall N, Roesli C, Takizawa H, Manz MG, Fugmann T, Neri D

      J Proteomics., 2014 Mar 17;99 :138-151. doi: 10.1016/j.jprot.2014.01.022

    • 13

      Fas (CD95) expression in myeloid cells promotes obesity-induced muscle insulin resistance

      Wueest S, Mueller R, Blüher M, Item F, Chin AS, Wiedemann MS, Takizawa H, Kovtonyuk L, Chervonsky AV, Schoenle EJ, Manz MG, Konrad D

      EMBO Mol Med., 2014 Jan ;6(1):43-56. doi: 10.1002/emmm.201302962

    • 12

      Engineering of a functional bone organ through endochondral ossification

      Scotti C#, Piccinini E#, Takizawa H#, Todorov A, Bourgine P, Papadimitropoulos A, Barbero A, Manz MG, Martin I*

      Proc Natl Acad Sci U S A., 2013, Mar 5;110(10):3997-4002. doi: 10.1073/pnas.1220108110

    • 11

      Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

      Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA*, Manz MG*

      Annu Rev Immunol., 2013;31:635-674. doi: 10.1146/annurev-immunol-032712-095921

    • 10

      In vivo divisional tracking of hematopoietic stem cells

      Takizawa H*, Manz MG

      Ann N Y Acad Sci., 2012 Aug;1266(1):40-46. doi: 10.1111/j.1749-6632.2012.06500.x

    • 9

      Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells

      Boettcher S, Ziegler P, Schmid MA, Takizawa H, van Rooijen N, Kopf M, Heikenwalder M, Manz MG*

      J Immunol., 2012 Jun 15;188(12):5824-5828. doi: 10.4049/jimmunol.1103253

    • 8

      Demand-adapted regulation of early hematopoiesis in infection and inflammation

      Takizawa H, Boettcher S, Manz MG*

      Blood, 2012 Mar 29;119(13):2991-3002. doi: 10.1182/blood-2011-12-380113

    • 7

      Ex vivo expansion of hematopoietic stem cells: mission accomplished?

      Takizawa H, Schanz U, Manz MG*

      Swiss Med Wkly., 2011 Dec 29;141:w13316. doi: 10.4414/smw.2011.13316

    • 6

      Bone marrow dendritic cell progenitors in mice sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes

      Schmid MA, Takizawa H, Baumjohann DR, Saito Y, Manz MG*

      Blood, 2011 Nov 3;118(18):4829-4840. doi: 10.1182/blood-2011-03-344960

    • 5

      Transgenic expression of human signal regulatory protein alpha in Rag2-/-gammac-/- mice improves engraftment of human hematopoietic cells in humanized mice

      Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG*, Flavell RA*

      Proc Natl Acad Sci U S A., 2011 Aug 9;108(32):13218-13223. doi: 10.1073/pnas.1109769108

    • 4

      Dynamic regulation of hematopoietic stem cell cycling

      Takizawa H, Manz MG*

      Cell Cycle., 2011 Jul 15;10(14):2246-2247. doi: 10.4161/cc.10.14.16197

    • 3

      Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

      Takizawa H#, Regoes RR#, Boddupalli CS, Bonhoeffer S, Manz MG*

      J Exp Med., 2011 Feb; 14;208(2):273-284. doi: 10.1084/jem.20101643

    • 2

      Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

      Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA*

      Proc Natl Acad Sci U S A., 2011 Feb 8;108(6):2378-2383. doi: 10.1073/pnas.1019524108

    • 1

      Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

      Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG*, Flavell RA*

      Proc Natl Acad Sci U S A., 2011 Feb 8; 108(6):2390-2395., doi: 10.1073/pnas.1019682108

    • 6

      Lnk/Sh2b3 regulates integrin αIIbβ3 outside in signaling in platelets leading to stabilization of developing thrombus in vivo

      Takizawa H#, Nishimura S#, Nishikii H, Takayama N, Oda A, Kakinuma S, Morita Y, Yamazaki S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu Ki, Nakauchi H, Takaki S, Eto K*

      J Clin Invest., 2010 Jan;120(1):179-190. doi: 10.1172/JCI39503

    • 5

      Humanized mice for modeling human infectious disease: challenges, progress, and outlook

      Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P

      Cell Host Microbe., 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006

    • 4

      Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals

      Takizawa H, Eto K, Yoshikawa A, Nakauchi H, Takatsu K, Takaki S*

      Exp Hematol., 2008 Jul; 36(7): 897-906. doi: 10.1016/j.exphem.2008.02.004

    • 3

      Macrophage tolerance: CD47-SIRP-alpha-mediated signals matter

      Takizawa H, Manz MG*

      Nat Immunoll., 2007 Dec; 8(12): 1287-1289. doi: 10.1038/ni1207-1287

    • 2

      Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk

      Takizawa H, Kubo-Akashi C, Nobuhisa I, Kwon SM, Iseki M, Taga T, Takatsu K, Takaki S*

      Blood, 2006 Apr 1; 107(7): 2968-2975. doi: 10.1182/blood-2005-05-2138

    • 1

      Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly

      Kubo-Akashi C, Iseki M, Kwon SM, Takizawa H, Takatsu K, Takaki S*

      Biochem Biophys Res Commun., 2004 Mar 5; 312(2): 356-362. doi: 10.1016/j.bbrc.2004.01.060

    • 13

      Mitochondrial Translation Drives Erythroid Differentiation via Iron Homeostasis

      Hitoshi Takizawa

      Gordon Research Conferences for Red Cells, June 4-9, 2023, Newport, USA

    • 12

      Erythroblast differentiation driven by mitochondrial translation

      Hitoshi Takizawa

      2023 Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies Symposium Feb 22-24 2023, Hawaii, USA

    • 11

      Microbiota-regulated hematopoiesis

      Hitoshi Takizawa

      Oct 20-21, 2022, KU-KAIST Symposium, Kumamoto, Japan

    • 10

      Inflammatory signals in malignant stem cells

      Hitoshi Takizawa

      The 6th International Workshop on Humanized Mice, Oct 12-14 2022, Kyoto, Japan

    • 9

      Innate Immune Signal-Regulated Hematopoiesis

      Hitoshi Takizawa

      The 61st American Society of Hematology Annual Meeting, Dec 7-10 2019, Orland, USA

    • 8

      Innate immune signal-instructed hematopoietic modulation

      Hitoshi Takizawa

      JSPS bilateral seminar JSPS-INSERM Symposium “Implications of senescence in age related disorders: Towards healthy aging”, Sept 5-6 2019, Paris, France

    • 7

      Inflammation-modulated early hematopoiesis

      Hitoshi Takizawa

      Zhujiang Summit on Hematology at the 3rd Annual Congress of Hematology, Aug 16-17,2019, Guangzhou, China

    • 6

      Early hematopoiesis translates microbial signals to intestinal tissue repair

      Hitoshi Takizawa

      24th Congress of European Hematology Association, 13-16th June 2019, Amsterdam, Netherland

    • 5

      Innate immune signal-instructed early hematopoiesis

      Hitoshi Takizawa

      JSPS bilateral seminar 2019 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies, Feb 19-21 2019, Hawaii, USA

    • 4

      Inflammation-instructed modification and alteration of early hematopoiesis

      Hitoshi Takizawa

      The 1st KU-KAIST joint symposium, Oct. 21-23, 2018, Daejeon, KAIST, Korea

    • 3

      Gram negative bacterial infection damages hematopoietic stem cell via direct activation of TLR4-TRIF innate immune signaling

      Hitoshi Takizawa

      Mar 7 2018, Daejoen, KAIST, Korea

    • 2

      Differential regulations of hematopoiesis through toll-like reception 4 signaling

      Hitoshi Takizawa

      JSPS bilateral seminar 2019 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies, Feb 21-23 2017, Hawaii, USA

    • 1

      Impact of Inflammation in Hematopoietic Stem Cell Behavior

      Hitoshi Takizawa

      JSPS bilateral seminar JSPS-NUS symposium, Jan 14-16, 2016, Singapore