Publication

Mobilization dynamics of bone marrow hematopoietic stem cells during hematopoietic regeneration

Johansson A, Khalilnezhad A, Takizawa H, Mizuno, Suda T, Umemoto T

Exp Hematol., 2024 Jul 13:104281. doi: 10.1016/j.exphem.2024.104281

Integrin-α9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia

Niibori-Nambu A, Wang CQ, Chin DWL, Chooi JY, Hosoi H, Sonoki T, Tham CY, Nah GSS, Cirovic B, Tan DQ, Takizawa H, Sashida G, Goh Y, Tng J, Fam WN, Fullwood MJ, Suda T, Yang H, Tergaonkar V, Taniuchi I, Li S, Chng WJ, Osato M

Gene., 2024 Jul 11;928:148761. doi: 10.1016/j.gene.2024.148761

Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia

Ong KOK, Mok MMH, Niibori-Nambu A, Du L, Yanagida M, Wang CQ, Bahirvani AG, Chin DWL, Koh CP, Ng KP, Yamashita N, Jacob B, Yokomizo T, Takizawa H, Matsumura T, Suda T, Lau JA, Tan TZ, Mori S, Yang H, Iwasaki M, Minami T, Asou N, Sun QY, Ding LW, Koeffler HP, Tenen DG, Shimizu R, Yamamoto M, Ito Y, Kham SKY, Yeoh AE, Chng WJ, Osato M

Exp Hematol., 2024 Jun 13:104255. doi: 10.1016/j.exphem.2024.104255

TCF7L2: A potential key regulator of antidepressant effects on hippocampal astrocytes in depression model mice

Koga Y, Kajitani N, Miyako K, Takizawa H, Boku S, Takebayashi M

J Psychiatr Res., 2024 Jan 6:170:375-386. doi: 10.1016/j.jpsychires.2024.01.007

Identification of the antidepressant effect of electroconvulsive stimulation-related genes in hippocampal astrocyte

Miyako K, Kajitani N, Koga Y, Takizawa H, Boku S, Takebayashi M

J Psychiatr Res., 2024 Jan 4:170:318-327. doi: 10.1016/j.jpsychires.2024.01.004

Phospholipid metabolic adaptation promotes survival of IDH2 mutant AML cells

Morishima T, Takahashi K, Chin D, Tokunaga K, Arima Y, Matsuoka M, Suda T, Takizawa H*

Cancer Sci., 2023 Oct 26. doi: 10.1111/cas.15994

Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals

Wang Y, Morishima T, Sezaki M, Sato R, Nakato G, Fukuda S, Kobiyama K, Ishii KJ, Li Y*, Takizawa H*

EMBO Rep., 2023 Oct 23:e57485. doi: 10.15252/embr.202357485

GPRC5C Drives Branched-Chain Amino Acid Metabolism in Leukemogenesis

Zhang YW, Velasco-Hernandez T, Mess J, Lalioti ME, Romero-Mulero MC, Obier N, Karantzelis N, Rettkowski J, Schönberger K, Karabacz N, Jäcklein K, Morishima T, Trincado JL, Romecin P, Martinez-Moreno A, Takizawa H, Shoumariyeh K, Renders S, Zeiser R, Pahl HL, Béliveau F, Hébert J, Lehnertz B, Sauvageau G, Menendez P, Cabezas-Wallscheid N*

Blood Adv., 2023 Aug 28;bloodadvances. 2023010460. doi: 10.1182/bloodadvances.2023010460

IL-6 Levels Correlate with Prognosis and Immunosuppressive Stromal Cells in Patients with Colorectal Cancer

Yamamoto T, Tsunedomi R, Nakajima M, Suzuki N, Yoshida S, Tomochika S, Xu M, Nakagami Y, Matsui H, Tokumitsu Y, Shindo Y, Watanabe Y, Iida M, Takeda S, Hazama S, Tanabe T, Ioka T, Hoshii Y, Kiyota A, Takizawa H, Kawakami Y, Ueno T, Nagano H*

Ann Surg Oncol., 2023 Aug;30(8):5267-5277. doi: 10.1245/s10434-023-13527-y

Humanized mouse models with endogenously developed human natural killer cells for in vivo immunogenicity testing of HLA class I-edited iPSC-derived cells

Flahou C, Morishima T, Higashi N, Hayashi Y, Xu H, Wang B, Zhang C, Ninomiya A, Qiu W-Y, Yuzuriha A, Suzuki D, Nakamura S, Manz M, Kaneko S, Hotta A, Takizawa H, Eto K*, Sugimoto N*

Biochem Biophys Res., 2023 Jun 25;662:76-83. doi: 10.1016/j.bbrc.2023.04.067

Exposure to microbial products followed by loss of Tet2 promotes myelodysplastic syndrome via remodeling HSCs

Yokomizo-Nakano T, Hamashima A, Kubota S, Bai J, Sorin S, Sun Y, Kikuchi K, Morii M, Iimori M, Kanai A, Iwama A, Huang G, Kurotaki D, Takizawa H, Matsui H, Sashida G

J Exp Med., 2023 Jul 3;220(7):e20220962. doi: 10.1084/jem.20220962

IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia

Liu X, Sato N, Yabushita T, Tamura M, Asada S, Fujino T, Fukushima T, Yonezawa T, Tanaka Y, Fukuyama T, Tsuchiya A, Shikata S, Iwamura H, Saito M, Kinouchi C, Komatsu K, Yamasaki S, Shibata T, Sasaki AT, Schibler J, Wunderlich M, O’Brien E, Mizukawa B, Mulloy JC, Sugiura Y, Takizawa H, Shibata T, Miyake K, Kitamura T, Goyama S*

EMBO Mol Med., 2023 Jan 11;15(1):e15631. doi: 10.15252/emmm.202115631

Hematopoietic stem and progenitor cells integrate microbial signals to promote post-inflammation gut tissue repair

Sezaki M^#, Hayashi Y^#, Nakato G, Wang Y, Nakata S, Biswas S, Morishima T, Fakruddin M, Moon J, Ahn S, Kim P, Miyamoto Y, Baba Y, Fukuda S, Takizawa H*

EMBO J., 2022 Nov 17;41(22):e110712. doi: 10.15252/embj.2022110712

Bone marrow imaging reveals the migration dynamics of neonatal hematopoietic stem cells

Takihara Y, Higaki T, Yokomizo T, Umemoto T, Ariyoshi K, Hashimoto M, Sezaki M, Takizawa H, Inoue T, Suda T, Mizuno H

Commun Biol. 2022 Aug 2;5(1):776. doi: 10.1038/s42003-022-03733-x

Quantitative analysis of sympathetic and nociceptive innervation across bone marrow regions in mice

Fujita S, Morikawa T, Tamaki S, Sezaki M, Takizawa H, Okamoto S, Kataoka K, Takubo K

Exp. Hematol., 2022 Aug-Sep;112-113:44-59.e6. doi: 10.1016/j.exphem.2022.07.297

IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice

Kovtonyuk LV, Caiado F, Garcia-Martin S, Manz EM, Helbling PM, Takizawa H, Boettcher S, Al-Shahrour F, Nombela-Arrieta C, Slack E, Manz MG*

Blood, 2022 Jan 6;139(1):44-58. doi: 10.1182/blood.2021011570

Inflammation regulates haematopoietic stem cells and their niche

Ho NP, Takizawa H*

Int. J. Mol. Sci., 2022 Jan 20;23(3):1125. doi: 10.3390/ijms23031125

Unique molecular and functional features of extramedullary hematopoietic stem and progenitor cell reservoirs in humans

Mende N, Bastos HP, Santoro A, Mahbubani KT, Ciaurro V, Calderbank EF, Quiroga Londoño M, Sham K, Mantica G, Morishima T, Mitchell E, LidonniciMR, Meier-Abt F, Hayler D, Jardine L, Curd A, Haniffa M, Ferrari G, Takizawa H, Wilson NK, Göttgens B, Saeb-Parsy K, Frontini M, Laurenti E

Blood, 2022 Jun 9;139(23):3387-3401. doi: 10.1182/blood.2021013450

Eliminating chronic myeloid leukemia stem cells by IRAK1/4 inhibitors

Tanaka Y, Takeda R, Fukushima T, Mikami K, Tsuchiya S, Tamura M, Adachi K, Umemoto T, Asada S, Watanabe N, Morishita S, Imai M, Nagata M, Araki M, Takizawa H, Fukuyama T, Lamagna C, Masuda ES, Ito R, Goyama S, Komatsu N, Takaku T, Kitamura T*

Nat Commun., 2022 Jan 12;13(1):271. doi: 10.1038/s41467-021-27928-8

Impact of cerebrovascular comorbidity on prognosis in Japanese patients undergoing PCI: 1-year data from Japanese multicenter registry (KICS)

Ahmed K, Arima Y, Tabata N, Ishii M, Sato R, Yamashita T, Yamanaga K, Takizawa H, Hokimoto S, Sueta D, Araki S, Fujisue K, Takashio S, Fujimoto K, Shimomura H, Tsunoda R, Hirose T, Sato K, Kikuta K, Sakaino N, Nakamura S, Yamamoto N, Matsumura T, Kajiwara I, Tayama S, Sakamoto T, Nakao K, Oshima S, Yamamoto E, Sakamoto K, Kaikita K, Matsushita K, Tsujita K

Heart Vessels., 2022 Jun;37(6):911-918. doi: 10.1007/s00380-021-01997-7

Remote control of neural function by X-ray-induced scintillation

Matsubara T, Yanagida T, Kawaguchi N, Nakano T, Yoshimoto J, Sezaki M, Takizawa H, Tsunoda SP, Horigane SI, Ueda S, Takemoto-Kimura S, Kandori H, Yamanaka A, Yamashita T*

Nat Commun., 2021 Jul 22;12(1):4478. doi: 10.1038/s41467-021-24717-1

CD271+CD51+PALLADIN- human mesenchymal stromal cells possess enhanced ossicle-forming potential

Sezaki M, Biswas S, Nakata S, Oshima M, Koide S, Ho NPY, Okamoto N, Miyamoto T, Iwama A, Takizawa H

Stem Cells Dev., 2021 Jul 15;30(14):725-735. doi: 10.1089/scd.2021.0021

Fit-For-All iPSC-Derived Q1 Cell Therapies and Their Evaluation in Humanized Mice with NK Cell Immunity.

Flahou C, Morishima T, Takizawa H, Sugimoto N*.

Front Immunol., 2021 Apr 2;12:662360. doi: 10.3389/fimmu.2021.662360

Autophagy is dispensable for the maintenance of hematopoietic stem cells in neonates

Hashimoto M, Umemoto T, Nakamura-Ishizu A, Matsumura T, Yokomizo T, Sezaki M, Takizawa H, Suda T*

Blood Adv., 2021 Mar 23;5(6):1594-1604. doi: 10.1182/bloodadvances.2020002410

Immuno-modulation of hematopoietic stem and progenitor cells in inflammation

Sezaki M^#, Hayashi Y^#, Wang Y, Johansson A, Umemoto T, Takizawa H*

Front Immunol., 2020 Nov 24;11:585367. doi: 10.3389/fimmu.2020.585367

Establishment of bone marrow-derived M-CSF receptor-dependent self-renewing macrophages

Nasser H^#, Adhikary P^#, Abdel-Daim A^#, Noyori O, Panaampon J, Kariya R, Okada S, Ma W, Baba M, Takizawa H, Yamane M, Niwa H, Suzu S*

Cell Death Discov., 2020 Jul 23;6:63. doi: 10.1038/s41420-020-00300-3

Genetic fingerprint defines hematopoietic stem cell pool size and function

Morishima T*, Takizawa H*

Haematologica, 2020 Mar;105(3):526-528. doi: 10.3324/haematol.2019.241299

Innate immune signal-mediated regulation and alterations in hematopoiesis

Hayashi Y, Takizawa H*

Rinsho Ketsueki. 2020;61(6):651-656. doi: 10.11406/rinketsu.61.651

iPSC-derived platelets depleted of HLA class-I are inert to anti-HLA class-I and NK cell immunity

Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, Akasaka M, Nakamura S, Higashi N, Xu H, Matsumoto T, Fujio K, Manz MG, Hotta A, Takizawa H, Eto K, Sugimoto N

Stem Cell Rep., 2020 Jan 14;14(1):49-59. doi: 10.1016/j.stemcr.2019.11.011

Discrimination of dormant and active hematopoietic stem cells by G₀ marker reveals dormancy regulation by cytoplasmic calcium

Fukushima T, Tanaka Y, Hamey FK, Chang CH, Oki T, Umemoto T, Asada S, Hayashi Y, Fujino T, Yonezawa T, Takeda R, Kawabata KC, Fukuyama T, Goyama S, Takizawa H, Ishihama Y, Honda H, Göttgens B, and Kitamura T*

Cell Rep., 2019 Dec 17;29(12):4144-4158.e7. doi: 10.1016/j.celrep.2019.11.061

Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia

Hayashi Y, Goyama S, Liu X, Tamura M, Asada S, Tanaka Y, Fukuyama T, Wunderlich M, O'Brien E, Mizukawa B, Yamazaki S, Matsumoto A, Yamasaki S, Shibata T, Matsuda K, Sashida G, Takizawa H, Kitamura T*

Nat Commun., 2019 Oct 25;10(1):4869. doi: 10.1038/s41467-019-12555-1

Fate distribution and regulatory role of human mesenchymal stromal cells in engineered hematopoietic bone organs

Bourgine PE, Fritsch K, Pigeot S, Takizawa H, Kunz L, Kokkaliaris KD, Coutu DL, Manz MG, Martin I, Schroeder T

iScience., 2019 Sep 27;19:504-513. doi: 10.1016/j.isci.2019.08.006

Hlf marks the developmental pathway for hematopoietic stem cells but not for erythroid-myeloid progenitors

Yokomizo T*, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, , Nakagata N, Mori S, Kurokawa M, Tenen DG, Osato M, Suda T*, Komatsu N

J Exp Med., 2019 Jul 1;216(7):1599-1614. doi: 10.1084/jem.20181399

Development of the Hematopoietic System: Role of Inflammatory Factors

Hayashi Y^#, Sezaki M^#, Takizawa H*

Wiley Interdiscip Rev Dev Biol., 2019 Jul;8(4):e341. doi: 10.1002/wdev.341

Thrombopoietin metabolically primes hematopoietic stem cells to megakaryocyte lineage differentiation

Nakamura-Ishizu A, Umemoto T, Matsumura T, Stumpf PS, Takihara Y, Takizawa H, O’Neil A, Abdul Majeed AB, MacArthur BD, and Suda T

Cell Rep., 2018 Nov 13;25(7):1772-1785. e6. doi: 10.1016/j.celrep.2018.10.059

Inflammation and early hematopoiesis

Takizawa H*, Hayashi Y

Rinsho Ketsueki. 2018;59(10):1955-1961. doi: 10.11406/rinketsu.59.1955

Engineered humanized bone organs maintain human hematopoiesis in vivo

Fritsch K, Pigeot S, Bourgine PE, Feng X, Schroeder T, Martin I, Manz MG, Takizawa H*

Exp Hematol., 2018 May;61:45-51. e5. doi: 10.1016/j.exphem.2018.01.004

Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness

Takizawa H*, Fritsch K, Kovtonyuk LV, Saito Y, Yakkala C, Jacobs K, Ahuja AK, Lopes M, Hausmann A, Hardt WD, Gomariz Á, Nombela-Arrieta C and Manz MG

Cell Stem Cell., 2017 Aug 3;21(2):225-240. doi: 10.1016/j.stem.2017.06.013

Impact of inflammation on early hematopoiesis and the microenvironment

Takizawa H*and Manz MG

Int J Hematol., 2017 Jul;106(1):27-33. doi: 10.1007/s12185-017-2266-5

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells and the Bone Marrow Microenvironment

Kovtonyuk LV, Fritsch K, Feng X, Manz MG, Takizawa H*

Front Immunol., 2016, Nov 14;7:502. doi: 10.3389/fimmu.2016.00502

MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia

Rauch PJ, Ellegast JM, Widmer CC, Fritsch K, Goede JS, Valk PJ, Löwenberg B, Takizawa H, Manz MG*

Blood, 2016 Nov 3;128(18):2253-2257. doi: 10.1182/blood-2016-04-711986

Hematopoietic stem cell response to inflammation

Takizawa H*

Rinsho Ketsueki. 2016 Aug;57(8):1059-1065. doi: 10.11406/rinketsu.57.1059

Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo

Kovtonyuk LV, Manz MG, Takizawa H*

Blood, 2016 Jun 23;127(25):3175-3179. doi: 10.1182/blood-2015-09-669929

LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance

Ziegler P, Boettcher S, Takizawa H, Manz MG, Brümmendorf TH

Ann Hematol., 2016 Jan;95(2):173-178. doi: 10.1007/s00277-015-2550-5

BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

Berres ML, Lim KP, Peters T, Price J, Takizawa H, Salmon H, Idoyaga J, Ruzo A, Lupo PJ, Hicks MJ, Shih A, Simko SJ, Abhyankar H, Chakraborty R, Leboeuf M, Beltrão M, Lira SA, Heym KM, Clausen BE, Bigley V, Collin M, Manz MG, McClain K, Merad M, Allen CE

J Exp Med., 2014 Apr 7;211(4):669-83. doi: 10.1084/jem.20130977

The analysis, roles and regulation of quiescence in hematopoietic stem cells

Nakamura-Ishizu A, Takizawa H, Suda T*

Development., 2014 Dec;141(24):4656-4666. doi: 10.1242/dev.106575

Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F

Lundberg P^#, Takizawa H^#, Kubovcakova L^#, Guo G, Hao-Shen H, Dirnhofer S, Orkin SH, Manz MG, Skoda RC

J Exp Med., 2014 Oct 20;211(11):2213-2230. doi: 10.1084/jem.20131371

A comprehensive surface proteome analysis of myeloid leukemia cell lines for therapeutic antibody development

Strassberger V, Gutbrodt KL, Krall N, Roesli C, Takizawa H, Manz MG, Fugmann T, Neri D

J Proteomics., 2014 Mar 17;99 :138-151. doi: 10.1016/j.jprot.2014.01.022

Fas (CD95) expression in myeloid cells promotes obesity-induced muscle insulin resistance

Wueest S, Mueller R, Blüher M, Item F, Chin AS, Wiedemann MS, Takizawa H, Kovtonyuk L, Chervonsky AV, Schoenle EJ, Manz MG, Konrad D

EMBO Mol Med., 2014 Jan ;6(1):43-56. doi: 10.1002/emmm.201302962

Engineering of a functional bone organ through endochondral ossification

Scotti C^#, Piccinini E^#, Takizawa H^#, Todorov A, Bourgine P, Papadimitropoulos A, Barbero A, Manz MG, Martin I*

Proc Natl Acad Sci U S A., 2013, Mar 5;110(10):3997-4002. doi: 10.1073/pnas.1220108110

Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA*, Manz MG*

Annu Rev Immunol., 2013;31:635-674. doi: 10.1146/annurev-immunol-032712-095921

In vivo divisional tracking of hematopoietic stem cells

Takizawa H*, Manz MG

Ann N Y Acad Sci., 2012 Aug;1266(1):40-46. doi: 10.1111/j.1749-6632.2012.06500.x

Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells

Boettcher S, Ziegler P, Schmid MA, Takizawa H, van Rooijen N, Kopf M, Heikenwalder M, Manz MG*

J Immunol., 2012 Jun 15;188(12):5824-5828. doi: 10.4049/jimmunol.1103253

Demand-adapted regulation of early hematopoiesis in infection and inflammation

Takizawa H, Boettcher S, Manz MG*

Blood, 2012 Mar 29;119(13):2991-3002. doi: 10.1182/blood-2011-12-380113

Ex vivo expansion of hematopoietic stem cells: mission accomplished?

Takizawa H, Schanz U, Manz MG*

Swiss Med Wkly., 2011 Dec 29;141:w13316. doi: 10.4414/smw.2011.13316

Bone marrow dendritic cell progenitors in mice sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes

Schmid MA, Takizawa H, Baumjohann DR, Saito Y, Manz MG*

Blood, 2011 Nov 3;118(18):4829-4840. doi: 10.1182/blood-2011-03-344960

Transgenic expression of human signal regulatory protein alpha in Rag2-/-gammac-/- mice improves engraftment of human hematopoietic cells in humanized mice

Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG*, Flavell RA*

Proc Natl Acad Sci U S A., 2011 Aug 9;108(32):13218-13223. doi: 10.1073/pnas.1109769108

Dynamic regulation of hematopoietic stem cell cycling

Takizawa H, Manz MG*

Cell Cycle., 2011 Jul 15;10(14):2246-2247. doi: 10.4161/cc.10.14.16197

Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

Takizawa H^#, Regoes RR^#, Boddupalli CS, Bonhoeffer S, Manz MG*

J Exp Med., 2011 Feb; 14;208(2):273-284. doi: 10.1084/jem.20101643

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA*

Proc Natl Acad Sci U S A., 2011 Feb 8;108(6):2378-2383. doi: 10.1073/pnas.1019524108

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG*, Flavell RA*

Proc Natl Acad Sci U S A., 2011 Feb 8; 108(6):2390-2395., doi: 10.1073/pnas.1019682108

Lnk/Sh2b3 regulates integrin αIIbβ3 outside in signaling in platelets leading to stabilization of developing thrombus in vivo

Takizawa H^#, Nishimura S^#, Nishikii H, Takayama N, Oda A, Kakinuma S, Morita Y, Yamazaki S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu Ki, Nakauchi H, Takaki S, Eto K*

J Clin Invest., 2010 Jan;120(1):179-190. doi: 10.1172/JCI39503

Humanized mice for modeling human infectious disease: challenges, progress, and outlook

Legrand N, Ploss A, Balling R, Becker PD, Borsotti C, Brezillon N, Debarry J, de Jong Y, Deng H, Di Santo JP, Eisenbarth S, Eynon E, Flavell RA, Guzman CA, Huntington ND, Kremsdorf D, Manns MP, Manz MG, Mention JJ, Ott M, Rathinam C, Rice CM, Rongvaux A, Stevens S, Spits H, Strick-Marchand H, Takizawa H, van Lent AU, Wang C, Weijer K, Willinger T, Ziegler P

Cell Host Microbe., 2009 Jul 23;6(1):5-9. doi: 10.1016/j.chom.2009.06.006

Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals

Takizawa H, Eto K, Yoshikawa A, Nakauchi H, Takatsu K, Takaki S*

Exp Hematol., 2008 Jul; 36(7): 897-906. doi: 10.1016/j.exphem.2008.02.004

Macrophage tolerance: CD47-SIRP-alpha-mediated signals matter

Takizawa H, Manz MG*

Nat Immunoll., 2007 Dec; 8(12): 1287-1289. doi: 10.1038/ni1207-1287

Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk

Takizawa H, Kubo-Akashi C, Nobuhisa I, Kwon SM, Iseki M, Taga T, Takatsu K, Takaki S*

Blood, 2006 Apr 1; 107(7): 2968-2975. doi: 10.1182/blood-2005-05-2138

Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly

Kubo-Akashi C, Iseki M, Kwon SM, Takizawa H, Takatsu K, Takaki S*

Biochem Biophys Res Commun., 2004 Mar 5; 312(2): 356-362. doi: 10.1016/j.bbrc.2004.01.060

Interplay between hematopoiesis and microbiome

Hitoshi Takizawa

The 66th American Society of Hematology, Dec 7-10, 2024 San Diego, USA

Inflammatoy Stress in Hematopoietic Stem Cell

Hitoshi Takizawa

The 9th International Forum on Stem cells, Oct 24-25, 2024 Tianjin, China

Hematopoietic Stem Cell Response to Microbial Signals

Hitoshi Takizawa

The 2nd Zhujiang Symposium on The Hematologic Oncology Basic and Clinical Translation Research, Apr 11-14, 2024, Guangzhou, China

Mitochondrial Translation Drives Erythroid Differentiation via Iron Homeostasis

Hitoshi Takizawa

Gordon Research Conferences for Red Cells, June 4-9, 2023, Newport, USA

Erythroblast differentiation driven by mitochondrial translation

Hitoshi Takizawa

2023 Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies Symposium Feb 22-24 2023, Hawaii, USA

Microbiota-regulated hematopoiesis

Hitoshi Takizawa

Oct 20-21, 2022, KU-KAIST Symposium, Kumamoto, Japan

Inflammatory signals in malignant stem cells

Hitoshi Takizawa

The 6th International Workshop on Humanized Mice, Oct 12-14 2022, Kyoto, Japan

Innate Immune Signal-Regulated Hematopoiesis

Hitoshi Takizawa

The 61st American Society of Hematology Annual Meeting, Dec 7-10 2019, Orland, USA

Innate immune signal-instructed hematopoietic modulation

Hitoshi Takizawa

JSPS bilateral seminar JSPS-INSERM Symposium “Implications of senescence in age related disorders: Towards healthy aging”, Sept 5-6 2019, Paris, France

Inflammation-modulated early hematopoiesis

Hitoshi Takizawa

Zhujiang Summit on Hematology at the 3rd Annual Congress of Hematology, Aug 16-17,2019, Guangzhou, China

Early hematopoiesis translates microbial signals to intestinal tissue repair

Hitoshi Takizawa

24th Congress of European Hematology Association, 13-16th June 2019, Amsterdam, Netherland

Innate immune signal-instructed early hematopoiesis

Hitoshi Takizawa

JSPS bilateral seminar 2019 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies, Feb 19-21 2019, Hawaii, USA

Inflammation-instructed modification and alteration of early hematopoiesis

Hitoshi Takizawa

The 1st KU-KAIST joint symposium, Oct. 21-23, 2018, Daejeon, KAIST, Korea

Gram negative bacterial infection damages hematopoietic stem cell via direct activation of TLR4-TRIF innate immune signaling

Hitoshi Takizawa

Mar 7 2018, Daejoen, KAIST, Korea

Differential regulations of hematopoiesis through toll-like reception 4 signaling

Hitoshi Takizawa

JSPS bilateral seminar 2019 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies, Feb 21-23 2017, Hawaii, USA

Impact of Inflammation in Hematopoietic Stem Cell Behavior

Hitoshi Takizawa

JSPS bilateral seminar JSPS-NUS symposium, Jan 14-16, 2016, Singapore