Exploring the Mysteries
in
Blood Stem Cell
We are taking a journey to uncover the mysteries in biology of hematopoietic stem cell (HSC),
blood-
forming cells and to open a door of new therapy for future biomedicine.
News
Research
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01
The influence of inflammation on HSC and immune cell function
We address the question how inflammation impacts on hematopoietic stem cell (HSC) and immune cell function using various inflammatory mouse models such as infection, autoimmunity, allergy etc. Our previous findings that HSC can adapt hematopoietic program to be resistant to infection, tissue damage via innate immune signals suggest potential linkages between inflammation and hematopoietic alterations such as clonal hematopoiesis and hematologic disorders.
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02
Aging effects on HSC cell fate decision and its microenvironment
Aging of hematopoietic system involves thymic involution, memory B/T cell expansion, enhanced myelopoiesis and HSC changes, all together increasing risk of inflammatory diseases and cancer in many organs. Thus, understanding of cell intrinsic (HSC) and extrinsic (niche) signals will help to develop a new measure to prevent/treat aging-associated diseases.
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03
Human HSC and its niche biology using next generation humanized mice
A developmental tissue engineering approach has allowed us to create human bone organs from human bone marrow-derived mesenchymal stromal cells, that can maintain functional HSCs. Through genetic manipulation, we study the cellular and molecular components of the human BM niche for understanding disease and preclinically testing new therapies.
PI
Understand of the physiology and pathophysiology of hematopoietic stem cells.
Publication
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Publications2021-2024 24Mobilization dynamics of bone marrow hematopoietic stem cells during hematopoietic regeneration
Johansson A, Khalilnezhad A, Takizawa H, Mizuno, Suda T, Umemoto T
Exp Hematol., 2024 Jul 13:104281. doi: 10.1016/j.exphem.2024.104281
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Publications2021-2024 23Integrin-α9 overexpression underlies the niche-independent maintenance of leukemia stem cells in acute myeloid leukemia
Niibori-Nambu A, Wang CQ, Chin DWL, Chooi JY, Hosoi H, Sonoki T, Tham CY, Nah GSS, Cirovic B, Tan DQ, Takizawa H, Sashida G, Goh Y, Tng J, Fam WN, Fullwood MJ, Suda T, Yang H, Tergaonkar V, Taniuchi I, Li S, Chng WJ, Osato M
Gene., 2024 Jul 11;928:148761. doi: 10.1016/j.gene.2024.148761
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Publications2021-2024 22Activation of NOTCH signaling impedes cell proliferation and survival in acute megakaryoblastic leukemia
Ong KOK, Mok MMH, Niibori-Nambu A, Du L, Yanagida M, Wang CQ, Bahirvani AG, Chin DWL, Koh CP, Ng KP, Yamashita N, Jacob B, Yokomizo T, Takizawa H, Matsumura T, Suda T, Lau JA, Tan TZ, Mori S, Yang H, Iwasaki M, Minami T, Asou N, Sun QY, Ding LW, Koeffler HP, Tenen DG, Shimizu R, Yamamoto M, Ito Y, Kham SKY, Yeoh AE, Chng WJ, Osato M
Exp Hematol., 2024 Jun 13:104255. doi: 10.1016/j.exphem.2024.104255
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Invited lectures 14Hematopoietic Stem Cell Response to Microbial Signals
Hitoshi Takizawa
The 2nd Zhujiang Symposium on The Hematologic Oncology Basic and Clinical Translation Research, Apr 11-14, 2024, Guangzhou, China
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Invited lectures 13Mitochondrial Translation Drives Erythroid Differentiation via Iron Homeostasis
Hitoshi Takizawa
Gordon Research Conferences for Red Cells, June 4-9, 2023, Newport, USA
Position
Message to prospective students
We are seeking for ambitious, forward-thinking students for master and PhD. Our lab provides those with strong motivation and passion toward science, an intellectual and technical opportunity to explore the world of blood system.
We are all committed to investigating the cellular and molecular mechanisms governing hematopoietic stem cell behavior in health and disease, and to making progress in and contributions to both basic science and clinical applications.
Your dedication to generate human knowledge and develop therapy will open new future in human society.
